Proteomic Analysis Provides Insights Into PPIP5K2 Function and Its Impact on Corneal Energy Metabolism
This study identified many proteins and energy-related pathways following the loss of PPIP5K2 in HCFs, suggesting a potential role of PPIP5K2 in regulating glycolysis in the cornea.
Authors
- Zhong Chen (ORCID: https://orcid.org/0000-0002-3618-5073)
- Stephen B. Shears (ORCID: https://orcid.org/0000-0001-7309-8916)
- Hongfang Yu
- Mitchell A. Watsky (ORCID: https://orcid.org/0000-0003-2079-9887)
- Yutao Liu
- Caili Hao (ORCID: https://orcid.org/0009-0006-6743-6222)
- Theresa Akoto (ORCID: https://orcid.org/0000-0002-2408-2800)
- Chunfang Gu
- Xiaowen Lu
- Xingjun Fan
- Wenbo Zhi
Institutions
- Augusta University (US)
- National Institute of Environmental Health Sciences (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1167/iovs.66.15.67
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- James and Jean Culver Vision Discovery Institute, Georgia Regents University
- Augusta University
- National Institutes of Health