Clinical utility of pre-treatment four-digit-resolution HLA genotyping to guide anti-tumor necrosis factor choice and concomitant immunomodulator use
Pre-treatment four-digit HLA testing informs on anti-TNF treatment choice and immunomodulator use. In HLA-DQA1*05:01 carriers, adalimumab monotherapy should be used and infliximab avoided. In HLA-DQA1*05:05 carriers, infliximab or adalimumab can be used with a concomitant immunomodulator. In patients who do not carry either HLA-DQA1*05:01 or HLA-DQA1*05:05, adalimumab monotherapy or infliximab with a concomitant immunomodulator are recommended.
Authors
- N Chanchlani
- Fagbemi Aa
- P M Goggin
- Harry Heath (ORCID: https://orcid.org/0000-0001-8068-0832)
- Simon Panter
- Ben Hope
- Mary‐Anne Morris
- James Goodhand (ORCID: https://orcid.org/0000-0003-3112-376X)
- Cathryn Preston
- Charles Murray (ORCID: https://orcid.org/0000-0001-6736-1546)
- Amer Azaz
- Gervais Lm
- Mowat Ce
- Ellen H. Richards (ORCID: https://orcid.org/0000-0002-0899-5300)
- Christopher Roberts (ORCID: https://orcid.org/0000-0002-6215-8044)
- Hasnain Jafferbhoy
- Anna J Pigott
- Sian Kirkham
- Nigel John Trudgill (ORCID: https://orcid.org/0000-0002-8040-8158)
- C Bewshea
- Phillip Mayhead
- Kevin Monahan
- Kevin Lewis
- J. Beckly
- Mark Tighe (ORCID: https://orcid.org/0000-0003-0755-8296)
- Stephen R. Gore
- David Elphick
- Mark Smith
- Rebecca Saich
- Wesley Ed
- Richard Shenderey
- Croft Nm
- Chuka Nwokolo (ORCID: https://orcid.org/0000-0001-6375-7690)
- Amanda Beale
- Vinod F. Patel
- Phoebe Hodges
- Anne M. Willmott
- Huw Greenish
- Deven Vani
- L Grellier
- Y. Al-Nuaimi
- Tony Chiew Keong Tham
- Deb Ghosh
- Pollok Rc
- Tariq Mahmood (ORCID: https://orcid.org/0000-0002-8492-0175)
- Timothy J. McDonald (ORCID: https://orcid.org/0000-0003-3559-6660)
- F. Martínez Torrente
- Andy CY Li
- A.T. Cole
- Vishal Kaushik
- Bruce McLain
- Charles PJ Charlton
- Triantos Christos
- N C Direkze
- Zahid Mahmood
- Jimmy K Limdi
- Helen Matthews
- James W Hart
- Paul J R Banim
- Anjan Dhar
- Sandip Sen
- Arvind Ramadas
- Assad Butt
- Stuart L Bloom
- J R Fraser Cummings
- Thankam Paul
- John N Gordon
- Richard Johnston
- B K Baburajan
- Matt W Johnson
- Jonathon Snook
- Melissa Smith
- Claire Bell
- John Mansfield
- Sheldon C Cooper
- Guy Chung-Faye
- Andy Bell
- Achuth Shenoy
- Stephen Bridger
- Gareth Jones
- John ME Fell
- Alison Simmons
- Sarah Langlands
- Chris Hawkey
- Sean Weaver
- Timothy Orchard
- Stephen M Evans
- Daniel R Gaya
- John S De Caestecker
- Simeng Lin
- David Watts
- Kasamu Dawa Kabiru
- Juan De La Revella Negro
- Rakesh Chaudhary
- Matthew J Brookes
- Rachel Nice
- Suranga Dharmisari
- Neil Shah
- Nicholas A Kennedy
- Lawrence Armstrong
- Veena Zamvar
- Alka Thakur
- Radhakrishnan Hariraj
- Cathryn Edwards
- Rebecca Smith
- Alistair McNair
- Anita Modi
- Subramaniam Ramakrishnan
- Richard K Russell
- Ailsa Hart
- Gill Watts
- Neeraj Prasad
- Shanika de Silva
- Tariq H Iqbal
- Bim Bhaduri
- Anton V J Gunasekera
- Stephen Foley
- Marcus Harbord
- Martyn Carter
- Simon Lal
- Rachel Cooney
- Senthil Murugesan
- Paul Dunckley
- Aminda N De Silva
- Sonia Bouri
- Zia Mazhar
- Julie Doherty
- Stephen J Lewis
- David Hobday
- Christian P Selinger
- James O Lindsay
- Palani Sathish Babu
- Anurag Agrawal
- Astor Rodrigues
- Richard Haigh
- Peter M Irving
- Mr Richard Miller
- Shaji Sebastian
- Tariq Ahmad
Institutions
- University of Exeter (GB)
- University of Cambridge (GB)
- Royal Devon & Exeter NHS Foundation Trust (GB)
- Cambridge University Hospitals NHS Foundation Trust (GB)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2025-12-17
- DOI
- https://doi.org/10.1093/ecco-jcc/jjaf233
- Citations
- 1
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 1.82