Clinical performance and effect of pre‐analytical variation of plasma pTau217 alone versus the plasma pTau217/Aβ42 ratio for the identification of amyloid pathology

Plasma pTau217 alone accurately identified amyloid pathology across five cohorts; the addition of Aβ42 did not consistently improve performance. While plasma pTau217 alone was stable under various storage conditions, the plasma pTau217/Aβ42 ratio and plasma Aβ42 alone were less stable. This instability could lead to misinterpretation of biomarker results and pose challenges for broad implementation in routine clinical practice worldwide.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108585
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Clinical performance and effect of pre‐analytical variation of plasma pTau217 alone versus the plasma pTau217/Aβ42 ratio for the identification of amyloid pathology

Joana Amorim Freire, Christina Rabe, Annunziata Di Domenico, Tobias Bittner et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Clinical performance and effect of pre‐analytical variation of plasma pTau217 alone versus the plasma pTau217/Aβ42 ratio for the identification of amyloid pathology

Joana Amorim Freire, Christina Rabe, Annunziata Di Domenico, Tobias Bittner, Christopher M. Rank, Alexander Jethwa, Colin L. Masters, Marc Suárez‐Calvet
article en

Abstract

Plasma pTau217 alone accurately identified amyloid pathology across five cohorts; the addition of Aβ42 did not consistently improve performance. While plasma pTau217 alone was stable under various storage conditions, the plasma pTau217/Aβ42 ratio and plasma Aβ42 alone were less stable. This instability could lead to misinterpretation of biomarker results and pose challenges for broad implementation in routine clinical practice worldwide.

Alzheimer s & DementiaVol. 21(S7)
Roche (Switzerland) (CH), Florey Institute of Neuroscience and Mental Health (AU), Roche Pharma AG (Germany) (DE), Pasqual Maragall Foundation (ES), Barcelonaβeta Brain Research Center (ES), Hospital Del Mar (ES)
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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