A novel human iNeuron tauopathy model identifies splicing and stress granule related RNA binding proteins as regulators of tau aggregation and toxicity
This work identified several novel regulators of tau aggregation and toxicity, including PNN and stress granule related proteins. Future work will examine the mechanism(s) by which these RBPs modulate tau aggregation and toxicity.
Authors
- Rohit Bose (ORCID: https://orcid.org/0000-0002-6785-0697)
- Gregory E. Merz (ORCID: https://orcid.org/0000-0003-0842-4935)
- Daniel R. Southworth (ORCID: https://orcid.org/0000-0001-7108-9389)
- Martin Kampmann (ORCID: https://orcid.org/0000-0002-3819-7019)
- S. R. Kaufman
- Man Wang (ORCID: https://orcid.org/0000-0001-5072-9594)
- Sarah Hoyle
- Abi Wee
- William W. Seeley
- Jannis Bücking
Institutions
- University of California, San Francisco (US)
- Heidelberg University (DE)
- Heidelberg University of Education (DE)
- Heidelberg Engineering (Germany) (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_099419
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00