Effects of Diabetes on Cognition and Brain Morphology among Middle‐aged and Older Adults without Dementia from Rural India

This study demonstrates that diabetes is associated with both cognitive impairments in the attention domain alongside grey matter loss in the bilateral cerebellum and right putamen even before the onset of dementia, highlighting the potential adverse impact of diabetes on brain health in rural Indians. Further, worsening glycaemic control among individuals with diabetes was associated with poorer attention. Therefore, early diagnosis and prompt interventions for diabetes could be a scalable and cost-effective strategy to reduce dementia risk in this population.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_105371
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Effects of Diabetes on Cognition and Brain Morphology among Middle‐aged and Older Adults without Dementia from Rural India

H.K. Pradhan, Ravi Muddashetty, Jonas S. Sundarakumar, SHRUTI PANDEY
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Effects of Diabetes on Cognition and Brain Morphology among Middle‐aged and Older Adults without Dementia from Rural India

H.K. Pradhan, Ravi Muddashetty, Jonas S. Sundarakumar, SHRUTI PANDEY
article en

Abstract

This study demonstrates that diabetes is associated with both cognitive impairments in the attention domain alongside grey matter loss in the bilateral cerebellum and right putamen even before the onset of dementia, highlighting the potential adverse impact of diabetes on brain health in rural Indians. Further, worsening glycaemic control among individuals with diabetes was associated with poorer attention. Therefore, early diagnosis and prompt interventions for diabetes could be a scalable and cost-effective strategy to reduce dementia risk in this population.

Alzheimer s & DementiaVol. 21(S6)
Indian Institute of Science Bangalore (IN)
Good health and well-being
Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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