Progression of Established Atherosclerotic Lesions Is Not Inhibited by Endothelial Knockout of Caveolin-1—Brief Report
Targeting CAV1 does not efficiently block LDL entry or reduce lesion progression in established atherosclerosis. These findings open several questions for further research, including alternative LDL entry mechanisms that could circumvent caveolar transport in established atherosclerosis.
Authors
- Jacob Fog Bentzon (ORCID: https://orcid.org/0000-0002-3020-5002)
- Leticia González-Cintado (ORCID: https://orcid.org/0000-0001-7050-3824)
- Marta Pulgarín-Alfaro (ORCID: https://orcid.org/0000-0003-3877-6771)
- Rocío Muñiz-Anquela
- Esmeralda A. Lewis (ORCID: https://orcid.org/0000-0003-0978-0851)
- Mónica Toledano-Donado (ORCID: https://orcid.org/0009-0004-9067-4400)
- Fidel-Nicolás Lolo
- Miguel A. del Pozo
- Ibon Redondo-Angulo
Institutions
- Steno Diabetes Centers (DK)
- Aarhus University Hospital (DK)
- Spanish National Centre for Cardiovascular Research (ES)
- Institute for Atherosclerosis Research (RU)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1161/atvbaha.125.323323
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00