Audiometric hearing and plasma biomarkers of Alzheimer's disease pathology and neurodegeneration in the Atherosclerosis Risk in Communities Neurocognitive Study
Poorer audiometric hearing in older adults is associated with plasma biomarkers of neurodegeneration, specifically NfL, but is not associated with AD-specific markers (amyloid and tau), suggesting that pathways linking hearing and ADRD are independent of these pathognomonic Alzheimer's-related brain changes.
Authors
- Jennifer A. Deal (ORCID: https://orcid.org/0000-0002-6985-048X)
- James Russell Pike (ORCID: https://orcid.org/0000-0002-6858-620X)
- Nicholas Simon Reed (ORCID: https://orcid.org/0000-0003-0410-6067)
- Priya Palta (ORCID: https://orcid.org/0009-0006-7153-5100)
- Bharat Thyagarajan (ORCID: https://orcid.org/0000-0001-6968-6985)
- Vidyulata Kamath (ORCID: https://orcid.org/0000-0001-7711-3597)
- Frank R Lin
- Josef Coresh
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Minnesota (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_106812
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00