Educational attainment mitigates cognitive decline associated with elevated pTau181 and APOE ε4 in Puerto Ricans
These results suggest that EA may enhance cognitive reserve and promote resilience to ADP in the PR population. Overall, high EA confers a cognitive advantage against functional decline in the presence of elevated pTau181. Furthermore, carrying the APOE ε4 allele increases the risk of cognitive decline in individuals with low EA compared to those with high EA. These findings underscore the importance of considering both educational background and genetic risk factors in efforts to understand and develop interventions to prevent cognitive decline globally.
Authors
- Daniel A. Dorfsman
- Patrice Whitehead
- Azizi Seixas
- Michael L. Cuccaro (ORCID: https://orcid.org/0000-0003-4769-0785)
- Kara L. Hamilton‐Nelson (ORCID: https://orcid.org/0000-0003-3748-7193)
- Katrina Celis
- Concepcion Silva‐Vergara
- Jeffery M. M Vance
- Briseida E. Feliciano‐Astacio (ORCID: https://orcid.org/0000-0003-4747-8928)
- Michael B. Prough
- Heriberto Acosta
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Glenies S Valladares
- Sabrina Mas
- Katalina McInerney
- Scaramutti Carolina
- Margaret Pericak‐Vance
- Vanessa C. Rodriguez
- Jose J. Sanchez
- Larry D Adams
- Farid Rajabli
- Mariangelie Lopez
- Dingtian Cai
Institutions
- University of Miami (US)
- Central University of the Caribbean (PR)
- Dr. John T. Macdonald Foundation (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_104908
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00