Tranexamic acid dosing in pediatric trauma: Dose simulation based on population pharmacokinetic modeling in adult trauma patients
In children with trauma-related bleeding, a TXA 25 mg/kg IV bolus is predicted to approximate the C<sub>max</sub> achieved with a 2 g IV bolus in adults. More frequent dosing may be necessary in children to achieve a similar total drug exposure as adults with trauma-related bleeding.
Authors
- Philip Charles Spinella (ORCID: https://orcid.org/0000-0003-1721-0541)
- Kevin J. Downes (ORCID: https://orcid.org/0000-0001-5015-8146)
- Kevin Watt (ORCID: https://orcid.org/0000-0002-5975-5091)
- Gideon A. Stitt (ORCID: https://orcid.org/0000-0001-5269-214X)
- Athena F. Zuppa (ORCID: https://orcid.org/0000-0002-8662-7474)
- Christine Leeper
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pittsburgh (US)
- University of Utah (US)
- University of Utah Hospital (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Transfusion
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1111/trf.70047
- Primary Topic
- Blood transfusion and management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Biomedical Advanced Research and Development Authority
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development