Altered spatiotemporal brain dynamics of interoception in behavioural‐variant frontotemporal dementia
Our findings suggest a core allostatic-interoceptive deficit occurs in people with bvFTD, captured by altered brain dynamics of intrinsic neural timescales. In AD, it is possible that a more generalised disruption of brain oscillation occurs. Altered interoceptive intrinsic neural timescales may provide a neurobiological mechanism underpinning the complex behaviours observed in bvFTD patients. Our findings support synergistic models of brain disease and can inform clinical practice.
Authors
- Agustín Ibáñez
- Gabriel Della Bella (ORCID: https://orcid.org/0000-0001-8433-0725)
- Sebastián Moguilner (ORCID: https://orcid.org/0000-0003-1731-8325)
- Jessica L. Hazelton (ORCID: https://orcid.org/0000-0002-0784-6071)
- Pablo Barttfeld
- Bruce L. Miller (ORCID: https://orcid.org/0000-0002-2152-4220)
- Marcelo Adrián Maito (ORCID: https://orcid.org/0009-0003-5909-7740)
- M. Gadea
- Yasir Çatal (ORCID: https://orcid.org/0000-0002-0942-899X)
- Jhosmary Cuadros (ORCID: https://orcid.org/0000-0001-7665-0171)
- Georg Northoff (ORCID: https://orcid.org/0000-0002-5236-0951)
- Martín Dottori
- Olivier Piguet (ORCID: https://orcid.org/0000-0002-4305-7897)
- Joaquin Migeot
- Agustina Legaz
- Hernan Hernandez
- Pavel Prado
- Raul Gonzalez‐Gomez
- Matias Fraile‐Vazquez
Institutions
- Universidad Nacional Experimental del Táchira (VE)
- The University of Sydney (AU)
- University of Kansas (US)
- Universidad Nacional de Córdoba (AR)
- University of California, San Francisco (US)
- Adolfo Ibáñez University (CL)
- Royal Ottawa Mental Health Centre (CA)
- San Sebastián University (CL)
- University of San Andrés (AR)
- Centro Científico Tecnológico - San Juan (AR)
- MIND Research Institute (US)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Communication University of Zhejiang (CN)
- Fertility & Lifespan Medical Institute (US)
- Global Brain Health Institute (US)
- Federico Santa María Technical University (CL)
- Zhejiang University (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109837
- Primary Topic
- Psychosomatic Disorders and Their Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00