Serum inflammatory biomarker profiles across the Alzheimer's disease spectrum in the Bio‐Hermes cohort
Serum inflammatory alterations, including 24 cytokines, strongly associate with cognitive status in Bio-Hermes, largely independent of amyloid pathology. Distinct inflammatory markers associate with APOEε4 genotype. Differences in biomarker correlation patterns and clinical associations highlight immune dysregulation across the AD spectrum. These findings reinforce inflammation's role in AD pathophysiology, suggesting avenues for biomarker development and immunomodulatory therapies, warranting longitudinal investigation.
Authors
- Dominic Ng (ORCID: https://orcid.org/0000-0002-7748-3296)
- Samuel Leighton (ORCID: https://orcid.org/0000-0002-3999-4204)
- Jonathan Cavanagh (ORCID: https://orcid.org/0000-0003-0640-8050)
- Fani Deligianni (ORCID: https://orcid.org/0000-0003-1306-5017)
- Craig Ritchie
- Zain S Hussain
Institutions
- Scottish Agricultural Science Agency (GB)
- University of St Andrews (GB)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108502
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00