Genetic associations between insulin resistance and memory performance/decline: A NACC cohort study
Genetic liability to IR as indicated by a TG:HDL-C PRS is associated with a small, but significant, association with better memory performance and slower memory decline. However, this effect is modified by comorbidities and APOE-ɛ4 and ɛ2 non-carrier status, suggesting a complex interplay between genetic risk for IR, comorbidities, as well as triglyceride and cholesterol metabolism. Future work with larger populations may clarify these relationships.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Sarah Biber
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Emma Nolan (ORCID: https://orcid.org/0000-0003-2135-7597)
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Phoebe Scollard
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Ashley Sawyer
- Paul K Crane
- Walter W. Kukull
- Shubhabrata Mukherjee
- Jesse Mez
- Michael L. Lee
- Sterling C. Johnson
Institutions
- Boston University (US)
- University of Wisconsin–Madison (US)
- Vanderbilt University (US)
- University of Washington (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_106817
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00