High human cytomegalovirus antigen expression in pediatric medulloblastoma tissue is associated with poor event-free survival
This study provides the first evidence linking high HCMV-LA expression to adverse outcomes and high-risk molecular features in pediatric MB. UL88 emerged as the most strongly expressed HCMV gene across MB samples. These findings suggest a potential prognostic and therapeutic role for HCMV in MB, warranting validation in larger, prospective cohorts.
Authors
- Martin U. Schuhmann (ORCID: https://orcid.org/0000-0001-9843-7486)
- María F. De la Cerda-Vargas (ORCID: https://orcid.org/0000-0002-3847-8777)
- Julian Zipfel (ORCID: https://orcid.org/0000-0003-4725-713X)
- Jens Schittenhelm (ORCID: https://orcid.org/0000-0002-9168-6209)
- Rudi Beschorner (ORCID: https://orcid.org/0000-0003-1109-915X)
- Ghazaleh Tabatabai (ORCID: https://orcid.org/0000-0002-3542-8782)
- Martin Ebinger
Institutions
- Universitätsklinikum Tübingen (DE)
- University Children's Hospital Tübingen (DE)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-12-19
- DOI
- https://doi.org/10.1093/noajnl/vdaf266
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00