Association of Lifecourse Factory Production Work and Lewy Body Neuropathology
This is the first study, to our knowledge, finding increased levels of verified Lewy Body neuropathology in those with "Production Occupations"-i.e., donors who reported working as factory workers, foremans, assemblers, among other occupations in their work histories. Additional precision categorizing industrial production and manufacturing exposure in their occupational histories is needed to identify specific drivers behind this association, which may include the direct exposure to environmental hazards including heavy metal exposure.
Authors
- Sarah Lim (ORCID: https://orcid.org/0000-0001-7355-239X)
- Eleanna M. Melcher
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Lauren Etter (ORCID: https://orcid.org/0000-0002-8921-4632)
- Fred B. Ketchum (ORCID: https://orcid.org/0000-0003-0195-8643)
- Kelly M. Bakulski (ORCID: https://orcid.org/0000-0002-9605-6337)
- Adrienne R.S. Lee
- Stephen A. Goutman (ORCID: https://orcid.org/0000-0001-8780-6637)
- Amanda DeWitt (ORCID: https://orcid.org/0000-0003-3190-3475)
- Aly Pfaff
- Rachel C. Otte
- Amy J.H. Kind
- Shahriar Salamat
- Megan L. Zuelsdorff
- Barbara B. Bendlin
- W. Ryan Powell
Institutions
- University of Southern California (US)
- University of Wisconsin–Madison (US)
- University of Michigan (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108660
- Primary Topic
- Pesticide Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 0.00