Assessing Blood‐Brain Barrier Integrity in Alzheimer’s Mouse Models: Implications for Therapeutic Delivery
The BBB permeability remains largely intact in the Tg2576 and 3Tg AD models. Our findings highlight the requirement of effective drug delivery strategies for AD therapeutics. This study also supports the need for a multi-method approach, incorporating both pharmacokinetic and imaging techniques, to thoroughly assess BBB integrity.
Authors
- Ulrich Bickel (ORCID: https://orcid.org/0000-0002-2721-299X)
- Ehsan Nozohouri (ORCID: https://orcid.org/0000-0002-1378-8955)
- Dhavalkumar D. Patel (ORCID: https://orcid.org/0000-0002-9175-8970)
- Sumaih Zoubi
- Behnam Noorani
- Yeseul Ahn
Institutions
- Texas Tech University (US)
- Texas Tech University Health Sciences Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108470
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00