Input‐output curve reveals slope of cortical hyperexcitability in early Alzheimer’s disease
TMS-EMG confirms evidence of increased cortical excitability in AD. This was evident at lower intensities with the RMT model (implicating voltage-gated Na+ channels) and higher intensities with the I/O Curve (implicating AMPA receptors). TMS may be useful to measure target engagement of novel therapies targeting cortical excitability in AD.
Authors
- Stephanie S. Buss (ORCID: https://orcid.org/0000-0002-9912-063X)
- Mouhsin M. Shafi (ORCID: https://orcid.org/0000-0002-4531-1967)
- Brice Passera (ORCID: https://orcid.org/0000-0001-9821-1970)
- Julia H Cho
- Daniel Z. Press (ORCID: https://orcid.org/0000-0001-6401-1305)
- Peter Fried
- Recep Ozdemir
- Martina Upton
- Emma Ferry
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Berenson Allen Center for Noninvasive Brain Stimulation (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110085
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00