Polygenic scores and baseline cognitive function in midlife
In this HRS cohort, more years of education were related to higher baseline cognition, and in individuals with European-ancestry, this relationship was partially mediated by a PGS for cognitive-function. Future directions include assessing the contribution of PGS to cognition over time, and investigating how environmental and life-course factors may moderate the association between PGS and cognition.
Authors
- Shana D. Stites (ORCID: https://orcid.org/0000-0003-3994-4343)
- Dawei Xie (ORCID: https://orcid.org/0000-0002-5065-7305)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Rebecca T. Brown (ORCID: https://orcid.org/0000-0001-7483-4137)
- Rory Boyle (ORCID: https://orcid.org/0000-0003-0787-6892)
- Nadia Dehghani (ORCID: https://orcid.org/0000-0002-0385-7267)
- Zuo Xi
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108618
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00