Multimorbidity, Cognition, and Alzheimer Disease Biomarkers: A Pathway Analysis

Among dementia-free individuals, greater multimorbidity burden was associated with biomarkers indicative of greater AD pathology, neurodegeneration, and cerebral SVD. Multimorbidity may contribute to cognition via both neurodegeneration and AD pathways.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70862_110144
Primary Topic
Chronic Disease Management Strategies
Type
article
Field-Weighted Citation Impact
0.00
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article

Multimorbidity, Cognition, and Alzheimer Disease Biomarkers: A Pathway Analysis

Meredith N. Braskie, Robert A. Rissman, Xiaqing Jiang, K Yaffe et al.
Alzheimer s & Dementia
Chronic Disease Management Strategies
article

Multimorbidity, Cognition, and Alzheimer Disease Biomarkers: A Pathway Analysis

Meredith N. Braskie, Robert A. Rissman, Xiaqing Jiang, K Yaffe, Leigh A Johnson, Sid E. O'Bryant
article en

Abstract

Among dementia-free individuals, greater multimorbidity burden was associated with biomarkers indicative of greater AD pathology, neurodegeneration, and cerebral SVD. Multimorbidity may contribute to cognition via both neurodegeneration and AD pathways.

Alzheimer s & DementiaVol. 21(S8)
University of Southern California (US), University of North Texas (US), University of North Texas Health Science Center (US), University of California, San Francisco (US), Southern States University (US)
Openalex Percentile: Top 30%
Chronic Disease Management Strategies
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