Transcriptional regulation of astrocyte heterogeneity and disease pathogenesis across six different neurodegenerative diseases and seven brain regions
Our analysis revealed astrocyte-specific molecular changes shared across six NDs and seven brain regions. These findings illuminate the common mechanism underlying different dementias and provide potential novel therapeutic targets.
Authors
- Shinnosuke Yamada (ORCID: https://orcid.org/0009-0000-0209-4942)
- Ibrahim Olabayode Saliu (ORCID: https://orcid.org/0000-0002-6182-5992)
- Wei Feng (ORCID: https://orcid.org/0000-0002-0048-4020)
- Erik S. Musiek
- Guoyan Zhao
- Ching On Wong
- Qingyun Li
Institutions
- Washington University in St. Louis (US)
- The Ohio State University Newark (US)
- Prevent Alzheimer’s Disease 2020 (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098860
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00