Polygenic Risk Scores and Age at Onset in Late‐Onset Alzheimer's Disease: Insights from a Multi‐Ancestry Cohort
Higher PRS is associated with earlier AAO, supporting its utility in identifying high-risk individuals. PRS models based on the first multi-ancestry GWAS represent progress but could improve with larger datasets. Incorporating genetic, environmental, and lifestyle factors may further enhance the accuracy of PRS in diverse populations. Analyses are underway with the new ADSP Release 5.
Authors
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Jovana Jovanovska
Institutions
- University of Wisconsin–Madison (US)
- Wisconsin Division of Public Health (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_104110
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00