U.S. POINTER: Topline Results of a Large Multisite Randomized Controlled Multidomain Lifestyle Intervention Trial

U.S. POINTER, the largest lifestyle intervention trial globally, successfully met ambitious recruitment goals and engaged a diverse, at-risk cohort while maintaining high retention and participation rates. The topline results will provide pivotal evidence on the effectiveness of multidomain interventions to improve cognition or slow decline in older U.S. adults, with high potential to inform public health initiatives aimed at reducing Alzheimer's disease and related dementia risk.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_096524
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
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article

U.S. POINTER: Topline Results of a Large Multisite Randomized Controlled Multidomain Lifestyle Intervention Trial

Heather M. Snyder, Deborah Felton, Claire E. Day, Darren R. Gitelman et al.
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

U.S. POINTER: Topline Results of a Large Multisite Randomized Controlled Multidomain Lifestyle Intervention Trial

Heather M. Snyder, Deborah Felton, Claire E. Day, Darren R. Gitelman, Maryjo Cleveland, M. Kivipelto, Robert A. Rissman, CHRISTY TANGNEY, Marjorie Howard, Valory Pavlik, Maria Carrillo, Richard Elbein, Laura D. Baker, L. Lovato, Ann Marie McDonald, Nancy Woolard, Susan Antkowiak, M. A. Espeland, Olivia Matongo, Benjamin J. Williams, REMA RAMAN, Ashley S. Alexander, Kathryn Papp, Sarah Farias, Sharon Wilmoth, Melissa Yu, Xiaoyan Iris Leng, Katherine Lambert, Rena R. Wing, the U.S. POINTER Study Group, Rachel A. Whitmer, Stephen Salloway
article en

Abstract

U.S. POINTER, the largest lifestyle intervention trial globally, successfully met ambitious recruitment goals and engaged a diverse, at-risk cohort while maintaining high retention and participation rates. The topline results will provide pivotal evidence on the effectiveness of multidomain interventions to improve cognition or slow decline in older U.S. adults, with high potential to inform public health initiatives aimed at reducing Alzheimer's disease and related dementia risk.

Alzheimer s & DementiaVol. 21(S6)
University of Southern California (US), Alzheimer's Association (US), Brigham and Women's Hospital (US), Harvard University (US), Baylor College of Medicine (US), Providence College (US), Brown University (US), Miriam Hospital (US), Butler Hospital (US), Karolinska Institutet (SE), Massachusetts General Hospital (US), Advocate Health Care (US), Kelsey Research Foundation (US), Wake Forest University (US), Rush University (US), University of California, Davis (US)
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Openalex Percentile: Top 35%
Dementia and Cognitive Impairment Research
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