CenTauR correlation with amyloid, atrophy and cognition across the Alzheimer’s Disease spectrum: A tau imaging study with <sup>18</sup> F‐MK6240 PET
This study has established regional CTR thresholds and the prevalence of MTL and cortical tau in CU, MCI and clinical AD. It has confirmed that cortical tau is rarely found below 60 CL of Aβ. Cortical CTR strongly correlates with cognitive impairment and atrophy, while tau restricted to the MTL is linked to mild memory impairment.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- Azadeh Feizpour
- Ralph N. Martins (ORCID: https://orcid.org/0000-0002-4828-9363)
- Rachel S. Mulligan
- Joanne S. Robertson
- Pierrick Bourgeat
- Christopher C. Rowe
- Colin L. Masters
- Paul Maruff
- Jurgen Fripp
- Antoine Leuzy
- Victor L. Villemagne
- Simon M. Laws
Institutions
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- Malmö University (SE)
- Lund University (SE)
- Florey Institute of Neuroscience and Mental Health (AU)
- Australian e-Health Research Centre (AU)
- CSIRO Health and Biosecurity (AU)
- Austin Health (AU)
- University of Gothenburg (SE)
- Macquarie University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109695
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00