Two new prenyl-substituted natural products from the endophytic fungus <i>Talaromyces</i> sp. XSJC-F4

Two new prenyl-substituted natural products, 10-(3'-methyl-2'-butenyl)-9-methylguanine (<b>1</b>) and 12-ketone-colletorin B (<b>2</b>), along with three known prenylated compounds-12-ketone-colletochlorin B (<b>3</b>), colletorin B (<b>4</b>), and colletochlorin B (<b>5</b>)-were isolated from the endophytic fungus <i>Talaromyces</i> sp. XSJC-F4. The structures of isolated compounds were identified by HRESIMS, NMR analysis, and compared with data from the literature. In addition, all compounds were evaluated for their antibacterial activities <i>in vitro</i>. All five compounds (<b>1</b>-<b>5</b>) exhibited good antibacterial activity against <i>Bacillus subtilis</i> with MIC values ranging from 8 to 64 μg/mL.