Characterizing metabolic, behavioural, and bone changes in a novel aging mouse model of sporadic Alzheimer’s disease
The increased fat, and decreased percentage of lean mass along with reduced movement and energy expenditure in the hAb mice may indicate metabolic dysfunction which may precede sAD development. Future steps include increasing the sample size and investigating sex differences between the hAb female and male mice to determine any sex specific changes.
Authors
- Wendy E. Ward (ORCID: https://orcid.org/0000-0001-9518-9608)
- Evelin Melekh (ORCID: https://orcid.org/0009-0005-9150-8700)
- Val A. Fajardo (ORCID: https://orcid.org/0000-0003-4500-3347)
- Shawn M. Beaudette (ORCID: https://orcid.org/0000-0002-8427-3959)
- Rebecca E. K. MacPherson (ORCID: https://orcid.org/0000-0002-1577-2658)
- Amélie AT Marais
- Emma L Cook
- Ryan RW Baranowski
- Jessica A Mrezar
Institutions
- Brock University (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108387
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00