Limited concordance between micronucleus and chromosomal aberration assays in medical radiation workers: Evidence from a tertiary hospital-based study

The MN assay shows limited concordance and diagnostic accuracy compared with the CA assay under chronic low-dose exposure conditions and therefore cannot be recommended as a standalone substitute. However, its consistently high NPV supports its use as an efficient rule-out tool within a tiered surveillance strategy, where negative MN results reliably exclude CA-detectable chromosomal damage and positive results trigger confirmatory CA testing.