A Multi‐Modal Medical Management and Lifestyle Randomized Clinical Trial Increases Cerebral Blood Flow and Lowers Diabetic Risk in Persons with Early Alzheimer's Disease: Results from The [PREVENTION] Trial
In this small sample, we found evidence that a multi-domain intervention focused on medical management, exercise, and a carbohydrate-restricted diet improved diabetic risk and CBF in patients with AD.
Authors
- John F. Hodes (ORCID: https://orcid.org/0000-0003-4823-2065)
- Emily S. Popa (ORCID: https://orcid.org/0000-0002-4950-0888)
- Gavin T. Kress (ORCID: https://orcid.org/0000-0001-5152-1170)
- Jennifer E. Bramen (ORCID: https://orcid.org/0000-0001-8967-0008)
- Jared C. Roach (ORCID: https://orcid.org/0000-0003-4524-0107)
- Molly K. Rapozo (ORCID: https://orcid.org/0009-0009-5721-9074)
- Ryan M. Glatt (ORCID: https://orcid.org/0000-0003-3038-7229)
- Kyron P. Pierce (ORCID: https://orcid.org/0009-0006-5753-9009)
- Susan Y. Bookheimer (ORCID: https://orcid.org/0000-0002-3417-5891)
- David A. Merrill (ORCID: https://orcid.org/0000-0003-2181-3839)
- William G. Sparks
- Colby B. Slyapich
- Cyrus A. Raji (ORCID: https://orcid.org/0000-0002-9086-0105)
- Claudia L. Wong
- Verna R. Porter
- Mihae Kim (ORCID: https://orcid.org/0000-0002-1607-4851)
- Ynez M. Tongson
- Prabha Siddarth
- Aarthi S. Ganapathi (ORCID: https://orcid.org/0000-0001-8201-055X)
- Stella E. Panos (ORCID: https://orcid.org/0000-0002-3014-6014)
- Tess Bookheimer
- Lee Hood
- Shannel H. K. Elhelou
- Karen J. Miller
- Andrea M Torres
Institutions
- University of Southern California (US)
- University of California, Los Angeles (US)
- Providence College (US)
- Washington University in St. Louis (US)
- Institute for Systems Biology (US)
- Mallinckrodt (United States) (US)
- Saint John's Health Center (US)
- Pacific Heart Institute (US)
- Drexel University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_099523
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00