Exploring connectedness as a source of cognitive resilience in Black middle‐aged and older adults: Social support, plasma <i>p</i> ‐tau217, and cognition

Greater availability of a key resource, social support, predicted better episodic memory but not speed and flexibility within this small, Black cohort. In contrast, p-tau217, a biomarker of AD pathology, was related to greater speed and flexibility but not episodic memory. Supportive social relationships may act on recall abilities independent of Alzheimer's-specific pathology: social support did not associate with p-tau217. Facilitating social connection may be a promising nonpharmacological intervention strategy in Black communities but future studies must examine the role for additional dementia pathologies, and in larger samples.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_107457
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring connectedness as a source of cognitive resilience in Black middle‐aged and older adults: Social support, plasma p ‐tau217, and cognition

Megan L. Zuelsdorff
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Exploring connectedness as a source of cognitive resilience in Black middle‐aged and older adults: Social support, plasma p ‐tau217, and cognition

Megan L. Zuelsdorff
article en

Abstract

Greater availability of a key resource, social support, predicted better episodic memory but not speed and flexibility within this small, Black cohort. In contrast, p-tau217, a biomarker of AD pathology, was related to greater speed and flexibility but not episodic memory. Supportive social relationships may act on recall abilities independent of Alzheimer's-specific pathology: social support did not associate with p-tau217. Facilitating social connection may be a promising nonpharmacological intervention strategy in Black communities but future studies must examine the role for additional dementia pathologies, and in larger samples.

Alzheimer s & DementiaVol. 21(S6)
University of Wisconsin–Madison (US)
Reduced inequalities
Openalex Percentile: Top 36%
Dementia and Cognitive Impairment Research
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