Biomarker‐integrated Prognostic Stagings for Alzheimer's Disease
A unified staging system integrating cognitive status, plasma pTau217, and age effectively stratifies AD progression risk and predicts cognitive decline. This framework provides a clinically actionable model to guide personalized treatment strategies and monitor therapeutic efficacy, especially in the era of disease-modifying therapies.
Authors
- Hyemin Jang (ORCID: https://orcid.org/0000-0001-8040-5371)
- Min Young Chun (ORCID: https://orcid.org/0000-0003-3731-6132)
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- K. Kim
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Seongmi Kim (ORCID: https://orcid.org/0009-0004-3144-9908)
- Sunghyun Kim (ORCID: https://orcid.org/0000-0002-9326-1028)
- Sungjoo Lee (ORCID: https://orcid.org/0000-0003-3564-4220)
- Sohyun Yim (ORCID: https://orcid.org/0000-0002-9357-768X)
- Kaj Blennow
- Duk Na
- Kyoungmin Kim (ORCID: https://orcid.org/0009-0000-4161-3573)
- Junpyo Kim
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Jehyun Ahn
- Sang Won Seo
- Jihwan Yun (ORCID: https://orcid.org/0009-0000-4084-7327)
- Heekyoung Kang (ORCID: https://orcid.org/0000-0003-0287-6818)
- Hee Jin Kim
- Soyeon Yoon
- K‐ROAD ADNI
- Michael S. W. Weiner
- Hee Kyung Park
- Henrik Zetterberg
Institutions
- University of California, San Francisco (US)
- Severance Hospital (KR)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- University Memory and Aging Center (US)
- Kyung Hee University Medical Center (KR)
- Yonsei University Health System (KR)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108341
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00