The Uganda Aging Cohort Study: Current Lessons and Future Opportunities

The Uganda Dementia Cohort Study will enhance our understanding of ADRDs including risk/protective factors, clinical phenotypes, diagnostic tools, societal impacts, and mechanisms among older persons with and without HIV in Uganda. The cohort is expanding to include deep-phenotyping through annual cognitive assessments, clinical examinations, plasma ADRD biomarkers, and brain imaging (Table 1). Household visits and interviews will be conducted to assess social and economic wellbeing and caretaker burden. The protocol is harmonised with other regional initiatives to facilitate future cross-national studies. Clinical and imaging datasets and a biobank will be created to promote harmonised/cross-national studies to better understand ADRDs in Africa. In summary, the UDCS aims to provide a rich source of data and specimens for dementia researchers in Africa and globally.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70860_100054
Primary Topic
HIV-related health complications and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

The Uganda Aging Cohort Study: Current Lessons and Future Opportunities

Noeline Nakasujja, Moses Acan, MJ Siedner, Jeremy A. Tanner et al.
Alzheimer s & Dementia
HIV-related health complications and treatments
article

The Uganda Aging Cohort Study: Current Lessons and Future Opportunities

Noeline Nakasujja, Moses Acan, MJ Siedner, Jeremy A. Tanner, Deanna R. Saylor, Edna Tindimwebwa, Samuel Maling, Zahra Reynolds, Alexander C. Tsai, Robert Paul, Flavia Atwine, Stephen Asiimwe
article en

Abstract

The Uganda Dementia Cohort Study will enhance our understanding of ADRDs including risk/protective factors, clinical phenotypes, diagnostic tools, societal impacts, and mechanisms among older persons with and without HIV in Uganda. The cohort is expanding to include deep-phenotyping through annual cognitive assessments, clinical examinations, plasma ADRD biomarkers, and brain imaging (Table 1). Household visits and interviews will be conducted to assess social and economic wellbeing and caretaker burden. The protocol is harmonised with other regional initiatives to facilitate future cross-national studies. Clinical and imaging datasets and a biobank will be created to promote harmonised/cross-national studies to better understand ADRDs in Africa. In summary, the UDCS aims to provide a rich source of data and specimens for dementia researchers in Africa and globally.

Alzheimer s & DementiaVol. 21(S6)
Mbarara University of Science and Technology (UG), The University of Texas at San Antonio Health Science Center (US), University of Missouri–St. Louis (US), University Teaching Hospital (ZM), Massachusetts General Hospital (US), Institute for Neurodegenerative Disorders (US), Joint Clinical Research Centre (UG), Makerere University (UG)
Good health and well-being
Openalex Percentile: Top 26%
HIV-related health complications and treatments
DOIOpen Access PDFOpenAlex
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