TPClust: Temporal Profile‐Guided Disease Subtyping Using High‐Dimensional Omics Data
Our integrative approach identified clinically meaningful AD subtypes with distinct cognitive trajectories, vascular profiles, and molecular signatures. These findings provide critical insights for precision medicine and targeted interventions in AD.
Authors
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Yuanjia Wang
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Philip L. De Jager
- David A. A. Bennett
- Boyi Hu
Institutions
- Columbia University Irving Medical Center (US)
- Rush University (US)
- Columbia University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_103996
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00