Estimating the total burden of multiple neuropathological changes

These analyses provide an initial validation that overall multi-pathological burden may be estimated from community pathology cohorts. Estimated weights of key neuropathological changes were externally validated. Future work will incorporate additional cohorts to refine estimated weights of microscopic infarcts and cerebral small vessel disease, incorporate uncommon neuropathological measures, and clarify the baseline risk of dementia in the absence of pathology.