Diffuse thyroid enlargement and its regression in methotrexate-associated lymphoproliferative disorder: an ultrasonographic observation
Patients receiving MTX therapy may develop MTX-LPD involving the thyroid gland. Thyroid MTX-LPD may present with concomitant worsening of hypothyroidism. Ultrasonographic findings in thyroid MTX-LPD can occasionally include diffuse thyroid enlargement. MALT lymphoma may occur as the histological subtype in primary thyroid MTX-LPD. MTX-LPD is expected to regress following discontinuation of MTX. Serial ultrasonographic monitoring of thyroid size can serve as an effective guide for assessing MTX-LPD regression.
Authors
- Yukihiro Fujita (ORCID: https://orcid.org/0000-0003-3238-8743)
- Shingo Murasawa (ORCID: https://orcid.org/0000-0002-6531-9923)
- Makoto Daimon (ORCID: https://orcid.org/0000-0002-3775-1719)
- Shinobu Takayasu (ORCID: https://orcid.org/0000-0003-4759-6166)
- Kazunori Kageyama (ORCID: https://orcid.org/0000-0003-0662-5231)
- Fumiya Isozaki
Institutions
- Hirosaki University (JP)
Publication Details
- Journal
- Endocrinology Diabetes and Metabolism Case Reports
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1530/edm-25-0062
- Citations
- 1
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.29