Influence of APOEε4 on Blood Transcriptomics in Cognitively Impaired Individuals
Our findings suggest the APOEε4 allele influences blood gene expression in CI individuals, leading to distinct transcriptomic signatures and pathophysiological pathways. Additionally, distinct gene expression patterns in carriers and non-carriers impact biomarker variability, notably FDG-PET and Aβ42.
Authors
- João Batista Teixeira da Rocha (ORCID: https://orcid.org/0000-0003-3829-0595)
- Christian Limberger (ORCID: https://orcid.org/0000-0002-5160-3886)
- Marco Antônio De Bastiani (ORCID: https://orcid.org/0000-0003-3924-5278)
- Marcelo Madrid de Bittencourt
- D N Souza
- Gabriela Mantovani Baldasso
- Eduardo R. Zimmer
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Instituto do Cérebro (BR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110084
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00