Hand function impairment in Systemic Sclerosis: determinants through investigations of clinical, radiographic and ultrasonographic features
our findings support the multifactorial origin of hand function impairment in SSc patients, with mostly contributions from cutaneous and MSK involvement. Skin fibrosis and US-detected tenosynovitis were the most significant variables explaining hand disability as measured by CHFS. Ultrasonography may represent a valuable complementary tool, assessing MSK disease severity and activity. WHAT WAS ALREADY KNOWN: cutaneous, vascular and musculoskeletal involvement contribute to hand function impairment in SSc patients WHAT WAS LEARNED FROM THIS STUDY: ● Skin fibrosis and US-detected tenosynovitis are the most relevant features. ● Ultrasonography may provide complementary information in the routine care of SSc patients.
Authors
- Marine Tas
- Veronica Codullo (ORCID: https://orcid.org/0000-0003-2557-8514)
- Sophie Hecquet (ORCID: https://orcid.org/0000-0002-9560-2594)
- S. Carvès (ORCID: https://orcid.org/0000-0001-9953-3867)
- Jérôme Avouac (ORCID: https://orcid.org/0000-0002-2463-218X)
- Carlomaurizio Montecucco
- Giulia Franchi
- Guillaume Coiffier
- Yannick Allanore
- Alain Lescoat
- Elena Marazzi
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- University of Pavia (IT)
- Université Rennes 2 (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Institut de Recherche en Santé, Environnement et Travail (FR)
- Policlinico San Matteo Fondazione (IT)
- Centre Hospitalier Universitaire de Rennes (FR)
- Université de Rennes (FR)
Publication Details
- Journal
- Seminars in Arthritis and Rheumatism
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1016/j.semarthrit.2025.152901
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00