Medial temporal lobe‐cortical connectivity is lower in older adults of African ancestry with the ABCA7‐80 risk allele but not in APOE‐ε4 carriers

APOE-ε4 and ABCA7-80 differentially shape MTL-parietal networks in preclinical stages of AD. The observed decrease in connectivity in ABCA7-80 carriers may reflect early dysfunction in neural networks involved in memory and attention. ABCA7-80 may therefore serve as an early marker of neural disruption in older adults of African ancestry, providing valuable insights for genotype-targeted interventions.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70861_108663
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Medial temporal lobe‐cortical connectivity is lower in older adults of African ancestry with the ABCA7‐80 risk allele but not in APOE‐ε4 carriers

Miray Budak, Soodeh Moallemian, Kelly Nudelman, Mark A. Gluck et al.
Alzheimer s & Dementia
Functional Brain Connectivity Studies
article

Medial temporal lobe‐cortical connectivity is lower in older adults of African ancestry with the ABCA7‐80 risk allele but not in APOE‐ε4 carriers

Miray Budak, Soodeh Moallemian, Kelly Nudelman, Mark A. Gluck, Payton Gabrielle White, Wiktoria Piaszczynska, Martina A. Ishaq, Bernadette A. Fausto
article en

Abstract

APOE-ε4 and ABCA7-80 differentially shape MTL-parietal networks in preclinical stages of AD. The observed decrease in connectivity in ABCA7-80 carriers may reflect early dysfunction in neural networks involved in memory and attention. ABCA7-80 may therefore serve as an early marker of neural disruption in older adults of African ancestry, providing valuable insights for genotype-targeted interventions.

Alzheimer s & DementiaVol. 21(S7)
Rutgers, The State University of New Jersey (US), Indiana University School of Medicine, Indiana University – Purdue University Indianapolis (US)
Openalex Percentile: Top 33%
Functional Brain Connectivity Studies
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Medial temporal lobe‐cortical connectivity is lower in older adults of African ancestry with the ABCA7‐80 risk allele but not in APOE‐ε4 carriers — Miray Budak, Soodeh Moallemian, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS