<i>APOE</i> 4 modifies the association between sleep apnea, inflammation, and tau pathology in older women
In women with OSA, APOE4 interacts with OSA severity to potentially precipitate a stronger inflammatory response and higher tau burden. Early diagnosis and treatment of OSA might mitigate AD risk, especially for older female APOE4 carriers.
Authors
- Ella T. Lifset (ORCID: https://orcid.org/0000-0003-2640-3206)
- Erin E. Sundermann (ORCID: https://orcid.org/0000-0001-5821-8035)
- Kitty K. Lui (ORCID: https://orcid.org/0000-0001-7586-0118)
- Xin Wang (ORCID: https://orcid.org/0000-0003-0314-9268)
- Nadine C. Heyworth
- Breanna Holloway
- Pamela N DeYoung
- Atul Malhotra
- Sarah J Banks
Institutions
- San Diego State University (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109805
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00