Age‐anchored genetic risk for Alzheimer’s disease is associated with markers of cerebrovascular disease, inflammation, and neurodegeneration in older adults without dementia

Increased genetic risk for AD in cognitively unimpaired older adults is associated with cerebrovascular burden, higher GFAP and NfL concentrations, and lower cognitive scores. White matter hyperintensities mediate the association between genetic risk for AD and cognition, including in individuals without evidence of amyloid, suggesting a role of cerebrovascular disease in genetic risk for clinical AD.