Cross‐ancestry prioritization of sex‐specific Alzheimer's disease risk genes through genetics and proteogenomics
Sex-stratified GWAS and PWAS identified 20 and 30 sex-specific AD loci/genes, respectively, with high sex heterogeneity accordance in exploratory African-admixed AD GWAS and PWAS. To provide validation and help prioritize probable causal genes at novel, significant GWAS/PWAS loci, colocalization analyses were performed with various QTL datasets (data not shown). These findings enhance our understanding of AD pathogenesis and risk, which may inform drug target development relevant to sex-specific personalized medicine.
Authors
- Yann Le Guen (ORCID: https://orcid.org/0000-0001-6649-8364)
- Daniel Western (ORCID: https://orcid.org/0000-0003-3725-9553)
- Danielle Marie Reid (ORCID: https://orcid.org/0000-0002-3316-9115)
- Ilaria Stewart (ORCID: https://orcid.org/0000-0002-8655-9387)
- Soomin C. Song (ORCID: https://orcid.org/0000-0002-9581-0991)
- Valerio Napolioni (ORCID: https://orcid.org/0000-0002-4378-6838)
- André Altmann (ORCID: https://orcid.org/0000-0002-9265-2393)
- Michael D. Greicius (ORCID: https://orcid.org/0000-0002-5462-9037)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Christina B. Young (ORCID: https://orcid.org/0000-0001-9535-2137)
- Michaël E. Belloy (ORCID: https://orcid.org/0000-0001-7748-9033)
- Aliza P. Wingo (ORCID: https://orcid.org/0000-0002-6360-6726)
- Yun Ju Sung
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Carlos Cruchaga
- Zihuai He
- Catherine Apio
- Noah Cook
- Chenyu Yang
- FinnGen
Institutions
- Università di Camerino (IT)
- Washington University in St. Louis (US)
- Quantitative BioSciences (US)
- Stanford Medicine (US)
- VA Northern California Health Care System (US)
- Institute of the Americas (US)
- University College London (GB)
- University of California, Davis (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_099094
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00