Sustainable supply of wilforic acid C <i>via</i> decompartmentalization of peroxisomal acetyl-CoA and systematic engineering in yeast
Decompartmentalization of peroxisomal acetyl-CoA in engineered S. cerevisiae enables 584.78 mg L −1 wilforic acid C, providing a sustainable platform for celastrol precursors and a generalizable strategy for the biosynthesis of acetyl-CoA products.
Authors
- Yanwei Hu (ORCID: https://orcid.org/0000-0001-9891-5310)
- Hao Tang
- Jiadian Wang
- Xiaoyi Wu
- Xuan Liu
- Luqi Huang
- Qin Xie
Institutions
- Nanjing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Green Chemistry
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1039/d5gc05378a
- Primary Topic
- Plant biochemistry and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00