Neuron‐Derived Extracellular Vesicles as a Blood‐Based Biomarker for Alpha‐Synuclein Across Synucleinopathies
NDE-associated aSyn is significantly elevated in synucleinopathy patients across multiple cohorts, supporting its potential as a blood-based biomarker. Further work is needed to standardize preanalytical conditions, establish a unified diagnostic threshold, and evaluate assay sensitivity at the individual level for clinical application.
Authors
- Olga V. Volpert (ORCID: https://orcid.org/0000-0003-1381-5543)
- Dina Ayupova
- Alexander Gekas
- Erez Eitan
Institutions
- NeuroBioTex (United States) (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_110157
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00