iPSC model of human specific neuroinflammation in Alzheimer’s disease
We found dual effect of CHRFAM7A on Aβ<sub>1-42</sub> associated pathology in AD: it provides protection against toxic concentration of Aβ<sub>1-42</sub> by decreased uptake through the humanized α7/CHRFAM7A nAChR and increases the innate immune response by switching the α7nAChR from an anti-inflammatory to pro-inflammatory transducer. Our iPSC model presents an opportunity to elucidate the molecular mechanism of these processes and establish high throughput screens.
Authors
- Ruea‐Yea Huang (ORCID: https://orcid.org/0000-0002-2630-3806)
- Ryu Dorn
- Ivanna Ihnatovych (ORCID: https://orcid.org/0000-0001-5861-787X)
- Kinga Szigeti
- Robin Schwartz
Institutions
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108756
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00