Global Burden of Alzheimer's Disease and Dementia: Trends in Mortality, Risk Factors and Incidence Across Sustainable Development Index Regions from 1990 to 2021

The global burden of Alzheimer's disease and other dementias is steadily rising, with high-SDI countries bearing the greatest burden due to modifiable risk factors like fasting plasma glucose and BMI. Despite lower rates in low-SDI countries, the upward trend is evident worldwide, with females consistently showing higher rates across all metrics. These findings underscore the urgent need for targeted prevention strategies and interventions to address this growing public health challenge.