Vitamin K suppression of ferroptosis in neuronal model systems

MK4 (vitamin K2) promotes survival of both proliferating and differentiated HT22 cells via suppression of ferroptosis induced by multiple pathways. GPX4 and the MK4 metabolizing enzymes (FSP1, VKORC1, VKORC1L1) are expressed in HT22 cells and likely cooperate to suppress ferroptosis in distinct cellular compartments.

Authors

Institutions

Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_097616
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Vitamin K suppression of ferroptosis in neuronal model systems

JoEllen Welsh, Carmen J Narvaez
Alzheimer s & Dementia
Ferroptosis and cancer prognosis
article

Vitamin K suppression of ferroptosis in neuronal model systems

JoEllen Welsh, Carmen J Narvaez
article en

Abstract

MK4 (vitamin K2) promotes survival of both proliferating and differentiated HT22 cells via suppression of ferroptosis induced by multiple pathways. GPX4 and the MK4 metabolizing enzymes (FSP1, VKORC1, VKORC1L1) are expressed in HT22 cells and likely cooperate to suppress ferroptosis in distinct cellular compartments.

Alzheimer s & DementiaVol. 21(S1)
University at Albany, State University of New York (US)
Openalex Percentile: Top 29%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.