Evaluating Single‐Domain and Multi‐Domain Interventions on Global Cognition in Cognitively Unimpaired Older Adults: A Network Meta‐Analysis
This network meta-analysis underscores the superior efficacy of multidomain interventions, particularly those combining PA and CT, in improving/maintaining global cognition among older adults. Long-term interventions amplify these benefits, reinforcing the importance of sustained, comprehensive approaches in addressing cognitive health. These results provide valuable insights for designing future prevention strategies targeting modifiable vascular and lifestyle-related risk factors.
Authors
- Oya Sayın (ORCID: https://orcid.org/0000-0003-0879-9091)
- Stefano Francesco Cappa (ORCID: https://orcid.org/0000-0003-1003-3925)
- Augusto J. Mendes (ORCID: https://orcid.org/0000-0002-9497-0707)
- Umberto Nencha (ORCID: https://orcid.org/0000-0002-2115-1823)
- Gabriele Volpara (ORCID: https://orcid.org/0000-0003-2158-2962)
- Federica Ribaldi (ORCID: https://orcid.org/0000-0001-9208-4472)
- Giulia Remoli
- Giorgi Khachvani
- Roberta Mulargia
- Giovanni B. Frisoni
- Stefano Giannoni‐Luza
Institutions
- University of Geneva (CH)
- University of Cagliari (IT)
- University of Pavia (IT)
- Istituto Universitario di Studi Superiori di Pavia (IT)
- University Hospital of Geneva (CH)
- Azienda Ospedaliera San Gerardo (IT)
- University of Bari Aldo Moro (IT)
- Geneva College (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_106615
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00