Disruptions in circadian rhythm alter amyloid‐dependent changes in tau and cognition
In a sample composed of CN and CI individuals, disruptions in CR measures were associated with older age and male sex. Higher relative amplitude of a RAR was associated with diminished cross-sectional and longitudinal tau accumulation and cognitive decline in people with elevated amyloid. These findings suggest robust CR may provide resilience to amyloid-related cognitive decline and tau accumulation and supports circadian dysfunction as a potentially modifiable risk factor for AD progression.
Authors
- Yi Rao (ORCID: https://orcid.org/0000-0002-0405-5426)
- Wai‐Ying Wendy Yau (ORCID: https://orcid.org/0000-0002-7597-7647)
- Valentina Pinilla
- Stephanie A. Schultz (ORCID: https://orcid.org/0000-0001-8460-4415)
- Gretchen Reynolds (ORCID: https://orcid.org/0000-0003-4838-5096)
- P H M Li
- Ina Djonlagic (ORCID: https://orcid.org/0000-0002-6951-3862)
- S. Redline
- Jasmeer P. Chhatwal (ORCID: https://orcid.org/0000-0002-7792-1698)
- S M Purcell
- Kailee Palmgren
- Eva N Pintucci
- Michael J. Properzi
- Keith A. Johnson
- Era Laho
- Yazmeen Usman
- Victoria Taieb
- Reisa A. Sperling
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Beth Israel Deaconess Hospital (US)
- Massachusetts General Hospital (US)
- Mass General Brigham (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70861_108850
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.00