Unravelling the significance of Fecal Micro RNA Profile in Alzheimer's Disease
Fecal miRNA profiles offer valuable insights into the gut-brain axis in Alzheimer's Disease and serve as promising non-invasive biomarkers for early diagnosis and disease monitoring. Altered miRNA expression reflects gut dysbiosis and neuroinflammatory responses, making them potential targets for therapeutic interventions. Future research should focus on validating these findings through large-scale clinical trials and exploring how dietary and probiotic treatments can modify miRNA expression to benefit AD patients. This review emphasizes the need for a multidisciplinary approach to better understand the role of the gut microbiome in neurodegenerative diseases and develop novel strategies for AD management.
Authors
- Prashant Bharadwaj (ORCID: https://orcid.org/0000-0003-4361-9906)
- Ralph N. Martins (ORCID: https://orcid.org/0000-0002-4828-9363)
- W. M. A. D Binosha Fernando
- Kavisha Sandaru Katuwawala
Institutions
- Edith Cowan University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_098838
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00