Unravelling the significance of Fecal Micro RNA Profile in Alzheimer's Disease

Fecal miRNA profiles offer valuable insights into the gut-brain axis in Alzheimer's Disease and serve as promising non-invasive biomarkers for early diagnosis and disease monitoring. Altered miRNA expression reflects gut dysbiosis and neuroinflammatory responses, making them potential targets for therapeutic interventions. Future research should focus on validating these findings through large-scale clinical trials and exploring how dietary and probiotic treatments can modify miRNA expression to benefit AD patients. This review emphasizes the need for a multidisciplinary approach to better understand the role of the gut microbiome in neurodegenerative diseases and develop novel strategies for AD management.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_098838
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Unravelling the significance of Fecal Micro RNA Profile in Alzheimer's Disease

Prashant Bharadwaj, Ralph N. Martins, W. M. A. D Binosha Fernando, Kavisha Sandaru Katuwawala
Alzheimer s & Dementia
Gut microbiota and health
article

Unravelling the significance of Fecal Micro RNA Profile in Alzheimer's Disease

Prashant Bharadwaj, Ralph N. Martins, W. M. A. D Binosha Fernando, Kavisha Sandaru Katuwawala
article en

Abstract

Fecal miRNA profiles offer valuable insights into the gut-brain axis in Alzheimer's Disease and serve as promising non-invasive biomarkers for early diagnosis and disease monitoring. Altered miRNA expression reflects gut dysbiosis and neuroinflammatory responses, making them potential targets for therapeutic interventions. Future research should focus on validating these findings through large-scale clinical trials and exploring how dietary and probiotic treatments can modify miRNA expression to benefit AD patients. This review emphasizes the need for a multidisciplinary approach to better understand the role of the gut microbiome in neurodegenerative diseases and develop novel strategies for AD management.

Alzheimer s & DementiaVol. 21(S1)
Edith Cowan University (AU)
Openalex Percentile: Top 37%
Gut microbiota and health
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