Influence of caloric restriction history, intermittent exposure to palatable food and sex in a binge eating model in C57BL/6J mice

This work is the first to compare the effects of the frequency of exposure to HFHS and a history of caloric restriction on binge eating behaviour in both male and female mice within a single experimental setting. The results do not reveal any major effects on binge eating behaviour but highlight the combination of both conditions for translational applications since any compensatory process is observed. Moreover, the results underscore a role of striatal Drd2 expression as a key factor involved in the course of BED.