Comparative Analysis of Adipose Tissue Depots in Immediate versus Delayed Breast Reconstruction

Omental fat in the IBR cohort has properties similar to those of subcutaneous WAT, indicating that the omentum is a promising candidate for rapid breast restoration. In the DBR group, the omentum molecular signature suggests a change towards a pro-fibrotic phenotype and a reduced remodeling capacity, suggesting that it should not be the primary choice for breast reconstruction. This study emphasizes the importance of careful WAT selection to minimize adverse outcomes, including cancer recurrence, and underscores the diverse physiology of fat depots.