Life Course Modifiable Risk Factors of Dementia: Replicating the 2024 Lancet Commission Model in a Single Longitudinal Cohort
Replication of the 2024 Lancet model in a single lifecourse longitudinal cohort revealed only a restricted subset of modifiable risk factors that associated with dementia odds, raising concern for publication bias potentially inflating risk estimates in meta-analytic approaches. History of mid-life hypertension consistently associated with reduced dementia risk, contrary to model predictions. Divergent risk profiles by ApoE-4 status highlight the importance of considering gene-by-environment interactions when formulating dementia risk models.
Authors
- Ralph Trane (ORCID: https://orcid.org/0000-0001-7824-1785)
- Michal Engelman (ORCID: https://orcid.org/0000-0002-3250-1921)
- Victoria J. Williams (ORCID: https://orcid.org/0000-0003-1834-3987)
- Kamil Sicinski
- Carol Roan
- Sanjay Asthana (ORCID: https://orcid.org/0000-0002-3998-4479)
- Pamela Herd
Institutions
- University of Wisconsin System (US)
- University of Wisconsin–Madison (US)
- University of Michigan (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70860_107692
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00