Association among cerebral glucose metabolism, mild behavioral impairment and cognition in autosomal‐dominant Alzheimer’s disease
Mutation carriers with MBI exhibited hypometabolism in an early AD-related region, partially explained by AD pathology; however, no memory performance differences were observed. These findings suggest that MBI may serve as a risk factor for disease progression, with neuropsychiatric symptoms potentially preceding both neurodegeneration and cognitive impairment. Expanding the sample size will be essential to strengthen the evidence and further investigate MBI as a promising marker for identifying high-risk individuals who may benefit from prevention strategies.
Authors
- Justin S. Sanchez (ORCID: https://orcid.org/0000-0003-4421-3078)
- Ana Baena (ORCID: https://orcid.org/0000-0002-5622-4519)
- Rosalinda Medrano
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Jennifer R. Gatchel (ORCID: https://orcid.org/0000-0002-3892-9742)
- Mónica Vidal (ORCID: https://orcid.org/0000-0003-2003-7954)
- Jorge Alcina
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Catarina Tristão‐Pereira (ORCID: https://orcid.org/0000-0001-9660-8341)
- Vincent Malotaux (ORCID: https://orcid.org/0000-0003-0737-9220)
- Sergio Castro Álvarez
- Díaz Vásquez
- David Fernando Aguillón Niño (ORCID: https://orcid.org/0000-0003-2283-536X)
- Lusiana Martinez
- Averi Giudicessi
- Bing He
- Natalia Londono
Institutions
- Boston University (US)
- Harvard University (US)
- McLean Hospital (US)
- University of Massachusetts Boston (US)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- Hospital Pablo Tobon Uribe (CO)
- Hologic (Germany) (DE)
- UCLouvain (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70862_109855
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00